Duplications play a significant role in both extremes of the phenotypic spectrum of newly arising mutations: they can have severe deleterious effects (e. g. duplications underlie a variety of diseases) but can also be highly advantageous. https://www.bekindtopets.com/special-offer-NFL-Miami-Dolphins-Team-Motto-iPhone-11-Pro-Max-Skin-p68856-flash-save/